Monoclonal anti-keratin antibody KL-1 (Immunotech, Marseille, France) and monoclonal anti-vimentin antibody M0725 (DAKO JAPAN, Kyoto, Japan) were used for this study. Immunohistochemical analysis for keratin and vimentin was carried out with the avidin-biotin peroxidase complex (ABC) method using formalin-fixed paraffin-embedded tissue sections. The content of estrogen receptor (ER) and progesterone receptor (PR) in the tumors was evaluated by using the dextran-coated charcoal method. Clinical data of patients were analyzed in conjunction with characteristics such as tumor size, contour, and lymph node metastasis. Tumors in which spindle cell components comprised less than half of the entire tumor were excluded from the category of spindle cell carcinoma. Neoplasms were eventually classified as spindle cell carcinoma if in situ and/or ductal, lobular, squamous, or mixed infiltrating carcinoma was contiguous or subtly merged with sheets of spindle-shaped cells. A total of 12 cases were identified from 1962 to 1995. Subjects and MethodsĪll breast tumors originally coded as carcinosarcoma or spindle cell carcinoma in Gunma University Hospital were retrieved and reviewed. We present herein three cases of breast spindle cell carcinoma with a cystic formation and review its characteristics from the literature. Despite its sarcomatous features, immunohistochemical studies have recently suggested that spindle components are likely to be derived from epithelial cells ( 4, 5). Since the histological arrangement of the spindle cell component resembles sarcoma, the category of ‘spindle cell carcinoma’ has been included in carcinoma with pseudosarcomatous metaplasia, carcinosarcoma, or metaplastic carcinoma ( 6). Spindle cell carcinoma consists of dominant spindle shape cells together with in situ /or ductal, lobular, squamous, or mixed infiltrating carcinoma ( 5). However, on rare occasions it occurs in the breast ( 3, 4). Spindle cell carcinoma is an unusual neoplasm commonly observed in the oral cavity ( 1) and the larynx ( 2). Spindle cell carcinoma, breast cancer, cystic formation, carcinosarcoma Introduction
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